An Investigation into the Effect of Various Penetration Enhancers on Percutaneous Absorption of Piroxicam

@article{Mortazavi2003AnII,
  title={An Investigation into the Effect of Various Penetration Enhancers on Percutaneous Absorption of Piroxicam},
  author={Seyed Alireza Mortazavi and Reza Aboofazeli},
  journal={Iranian Journal of Pharmaceutical Research},
  year={2003},
  volume={2},
  pages={135-140}
}
Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermatological products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to evaluate the effect of incorporating a few common penetration enhancers (in different concentrations) into a 0.5% w/w piroxicam (model drug) gel formulation, on the permeability rate of drug through rat abdominal skin in vitro. For this purpose various… 

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References

SHOWING 1-10 OF 29 REFERENCES

Action of penetration enhancers on human skin as assessed by the permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique.

TLDR
Azone was considerably more effective when used in conjunction with PG compared to an aqueous vehicle; thus PG itself may play an accelerating role in promoting the absorption through human skin of model drugs 5-fluorouracil and estradiol.

In vitro topical delivery of non-steroidal anti-inflammatory drugs through human skin.

TLDR
Evaluated in vitro the percutaneous absorption of non-steroidal anti-inflammatory drugs formulated as gels show that ketoprofen and piroxicam have the best rank order followed by niflumic acid, diclofenac sodium and epolamine dicL ofenac.

Effect of penetration enhancers on the permeation of mannitol, hydrocortisone and progesterone through human skin

TLDR
The results suggest that mannitol penetrated via a polar route, hydrocortisone by a mainly lipid route and progesterone via a lipid pathway but its penetration rate was probably affected by aqueous layers.

Effect of oleic acid on diffusion of drugs through hairless mouse skin.

The effect of oleic acid in propylene glycol or 2-ethyl-1,3-hexanediol vehicle systems on the skin permeability of 17 beta-estradiol, triamcinolone acetonide and trifluorothymidine was studied in

Synergistic effect of low-frequency ultrasound and surfactants on skin permeability.

TLDR
Investigating the synergistic effect of ultrasound and surfactants on transdermal drug delivery found that surfactant possessing anionic and cationic head groups were more potent than those possessing nonionic head groups in increasing skin conductivity in the presence of ultrasound.