An Invertron-Like Linear Plasmid Mediates Intracellular Survival and Virulence in Bovine Isolates of Rhodococcus equi.

@article{ValeroRello2015AnIL,
  title={An Invertron-Like Linear Plasmid Mediates Intracellular Survival and Virulence in Bovine Isolates of Rhodococcus equi.},
  author={Ana Valero-Rello and Alexia Hapeshi and Elisa Anastasi and Sonsiray Alvarez and Mariela M. Scortti and Wim G. Meijer and Iain MacArthur and Jose Vazquez-Boland},
  journal={Infection and immunity},
  year={2015},
  volume={83 7},
  pages={2725-37}
}
We report a novel host-associated virulence plasmid in Rhodococcus equi, pVAPN, carried by bovine isolates of this facultative intracellular pathogenic actinomycete. Surprisingly, pVAPN is a 120-kb invertron-like linear replicon unrelated to the circular virulence plasmids associated with equine (pVAPA) and porcine (pVAPB variant) R. equi isolates. pVAPN is similar to the linear plasmid pNSL1 from Rhodococcus sp. NS1 and harbors six new vap multigene family members (vapN to vapS) in a vap… CONTINUE READING
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The vapA co-expressed

  • CA Boland, JA Vazquez-Boland, WG. Meijer
  • 2011

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