An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression

  title={An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression},
  author={Philipp Becker and Natalia Sacilotto and Svanhild Nornes and Alice Neal and Max Thomas and Ke Liu and Chris Preece and Indrika D Ratnayaka and Benjamin Davies and George Bou-Gharios and Sarah de Val},
  booktitle={Arteriosclerosis, thrombosis, and vascular biology},
OBJECTIVE The vascular endothelial growth factor (VEGF) receptor Flk1 is essential for vascular development, but the signaling and transcriptional pathways by which its expression is regulated in endothelial cells remain unclear. Although previous studies have identified 2 Flk1 regulatory enhancers, these are dispensable for Flk1 expression, indicating that additional enhancers contribute to Flk1 regulation in endothelial cells. In the present study, we sought to identify Flk1 enhancers… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS


Publications referenced by this paper.
Showing 1-10 of 11 references

Foxn 4 directly regulates tbx 2 b expression and atrioventricular canal formation

  • NC Chi, RM Shaw, +4 authors Stainier DYR
  • Genes Dev
  • 2008

Sox 18 and Sox 7 play redundant roles in vascular development

  • S Cermenati, S Moleri, +7 authors M Beltrame
  • Blood
  • 2008

Mef 2 c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell - specific enhancer

  • Anderson JP De Val S, Khiem D Heidt AB, Black BL. Xu S-M
  • Dev Biol
  • 2004

The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis

  • Tautz D Sieger D, M. Gajewski
  • Mech Dev
  • 2003

Similar Papers

Loading similar papers…