An Introduction to Bioactivity of Fucoidan

@article{Tutuncu2019AnIT,
  title={An Introduction to Bioactivity of Fucoidan},
  author={Merve Tutuncu},
  journal={Biomedical Journal of Scientific \& Technical Research},
  year={2019}
}
  • Merve Tutuncu
  • Published 2019
  • Chemistry
  • Biomedical Journal of Scientific & Technical Research
Fucoidan is a polysaccharide, which is derived from brown algae and some marine invertebrates, consisting mainly of L-fucose and sulfate ester groups [1]. Fucoidan is particularly found in the cell wall of marine brown algae. This polysaccharide is named as fucoidin when it is derived from the first marine brown algae. Kylin gave Fucoidin in 1913. However, this name has been changed to fucoidan according to IUPAC rules [2]. Fucoidan related different studies have performed in the literature [1… Expand

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TLDR
This review summarizes the research progress on the structure and bioactivity of fucoidan and the relationships between structure andBioactivity and several fucoidans’ structures have been solved. Expand
Fucoidan present in brown algae induces apoptosis of human colon cancer cells
TLDR
The findings of this study indicate that fucoidan induces apoptosis in HT-29 and HCT116 human colon cancer cells, and that this phenomenon is mediated via both the death receptor-mediated and mitochondria-mediated apoptotic pathways. Expand
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In the future, much attention is supposed to be paid to unraveling the structural, compositional, and sequential properties of marine carbohydrate as well. Expand
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Evidence is provided demonstrating that the pro-apoptotic effect of fucoidan is mediated through the activation of ERK, p38 and the blocking of the PI3K/Akt signal pathway in HCT-15 cells, which supports the hypothesis that fuCOidan may have potential in colon cancer treatment. Expand
Interference with the CXCL12/CXCR4 axis as potential antitumor strategy: superiority of a sulfated galactofucan from the brown alga Saccharina latissima and fucoidan over heparins.
The present study demonstrates that fucose-containing sulfated polysaccharides (FCSP) from brown algae interfere with the CXCL12/CXCR4 axis in human Burkitt's lymphoma cells by binding CXCL12 andExpand
Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer
TLDR
It is shown that fucoidan inhibits tumor viability by activating the TLR4/ROS/ER stress axis and the downstream PERK-ATF4-CHOP pathway, leading to apoptosis and suppression of lung cancer cell progression, and this study is the first to identify a novel mechanism for the antitumor activity offucoidan. Expand
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Discussion is given primarily on the anti-inflammatory functions of mammalian heparins, heparin sulfate, chondroitin sulfATE, dermatan sulfate and related compounds as well as the holothurian fucosylated chond Detroitin sulfates and the brown algal fucoidans. Expand
Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines.
TLDR
Fucoidan is an effective antitumor agent, either alone or in combination with cisplatin, doxorubicin and taxol in MCF-7 breast cancer cells, and is a promising candidate for cancer combination therapies. Expand
Fucoidan protects mesenchymal stem cells against oxidative stress and enhances vascular regeneration in a murine hindlimb ischemia model.
TLDR
Results show that fucoidan protects MSCs from ischemia-induced cell death by modulation of apoptosis-associated proteins and cellular ROS levels through regulation of the MnSOD and Akt pathways, suggesting thatfucoidan could be powerful therapeutic adjuvant for MSC-based therapy in ischemic diseases. Expand
Low Molecular Weight Fucoidan Improves Endoplasmic Reticulum Stress-Reduced Insulin Sensitivity through AMP-Activated Protein Kinase Activation in L6 Myotubes and Restores Lipid Homeostasis in a Mouse Model of Type 2 Diabetes
TLDR
The findings suggest that AMPK activation by LMWF could prevent metabolic diseases by controlling the ER stress-dependent pathway and that this beneficial effect of LMWf provides a potential therapeutic strategy for ameliorating ER stress -mediated metabolic dysfunctions. Expand
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