An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.

@article{Leung2015AnID,
  title={An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.},
  author={Daisy W Leung and Dominika Borek and Priya Luthra and Jennifer M Binning and Manu Anantpadma and Gai F Liu and Ian B Harvey and Zhaoming Su and Ariel C Endlich-Frazier and Juanli Pan and Reed S Shabman and Wah Chiu and Robert A Davey and Zbyszek Otwinowski and Christopher F Basler and Gaya K Amarasinghe},
  journal={Cell reports},
  year={2015},
  volume={11 3},
  pages={376-89}
}
During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an RNA-template-bound form and a template-free form to provide the viral polymerase access to the RNA template. In addition, newly synthesized NP must be prevented from indiscriminately binding to noncognate RNAs. Here, we investigate the molecular bases for these critical processes. We identify an intrinsically disordered peptide derived from EBOV VP35 (NPBP, residues 20-48) that binds NP with high affinity… CONTINUE READING
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Filoviridae:Marburg and Ebola Viruses

  • A. Sanchez, T. W. Geisbert, H. Feldmann
  • 2006
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