An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging

@inproceedings{Yuan2015AnIM,
  title={An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging},
  author={Tian Yuan and Yinming Jiao and Simone de Jong and Roel A. Ophoff and Stephan Beck and Andrew E. Teschendorff},
  booktitle={PLoS genetics},
  year={2015}
}
Recent studies have demonstrated that the DNA methylome changes with age. This epigenetic drift may have deep implications for cellular differentiation and disease development. However, it remains unclear how much of this drift is functional or caused by underlying changes in cell subtype composition. Moreover, no study has yet comprehensively explored epigenetic drift at different genomic length scales and in relation to regulatory elements. Here we conduct an in-depth analysis of epigenetic… CONTINUE READING
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