• Corpus ID: 15592108

An Integrative Approach to Fibroids, Endometriosis, and Breast Cancer Prevention

  title={An Integrative Approach to Fibroids, Endometriosis, and Breast Cancer Prevention},
  author={Joel M. Evans},
W hat do fibroids, endometriosis, and breast cancer have in common? Estrogen. This hormone is a contributing factor in the growth of fibroid tumors, endometriosis lesions, and many breast carcinomas. In fact, estrogen-sensitive breast cancers are the most common type of breast cancer. Translated, this means that increases in estrogen production and decreases in estrogen elimination are potentially harmful for the body. Inflammation—a biologic process now implicated as fundamental in many… 

A Study on Clinico-Pathological Profile of Breast Cancer Patients and Their Correlation With Uterine Fibroids Using Hormone Level and Receptor Status Assessment

The prevalence of uterine fibroids in the study group of breast cancer patients was found to be high, and the role of estrogen and progesterone in the pathophysiology of both diseases and the common risk factors involved may biologically explain this finding.

Increased risk of breast cancer in women with uterine myoma: a nationwide, population-based, case-control study

A minor increased risk of breast cancer was found in women with a history of uterine myoma, and this association remained in patients with recent hormone use.

Factors associated with deep infiltrating endometriosis versus ovarian endometrioma in China: a subgroup analysis from the FEELING study

Results showed that women with any siblings, gastrointestinal symptoms during menstruation, or eating a greater number of fruit/vegetables per day were more likely to be diagnosed with DIE, while eating organic food and experiencing stress were major factors that are associated with the diagnosis of OMA.

Association between Exposure to Estrogenic Endocrine Disruptors - Polychlorinated Biphenyls, Phthalates, and Bisphenol A and Gynecologic Cancers- Cervical, Ovarian, Uterine Cancers

The findings point to a possible association between environmental exposure to PCBs and an increased risk of cervix, ovarian and uterine cancer.

Integrated Bioinformatics, Environmental Epidemiologic and Genomic Approaches to Identify Environmental and Molecular Links between Endometriosis and Breast Cancer

The findings suggest that breast cancer and endometriosis share some common environmental and molecular risk factors.

Uterine Fibroid Symptom Severity and Impact on Health-Related Quality of Life Among African American Women

Uterine Fibroid Symptom Severity and Impact on Health-Related Quality of Life Among African American Women and Clinicians’ Opinions on Treatment and Outcomes are Uncertain.



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Raloxifene is as effective as tamoxifen in reducing the risk of invasive breast cancer and has a lower risk of thromboembolic events and cataracts but a nonstatistically significant higher risk of noninvasive breast cancer.

Effects of pesticides on the ratio of 16 alpha/2-hydroxyestrone: a biologic marker of breast cancer risk.

Assays of this ratio, which can be measured in spot urines, may prove useful for a variety of in vitro and in vivo studies bearing on breast cancer risk, and may provide a marker for the risk of breast cancer.

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Findings support the hypothesis that I3C-induced estrogen 2-hydroxylation results in decreased concentrations of several metabolites known to activate the estrogen receptor, which may lower estrogenic stimulation in women.

Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention.

Formation of 1,4-GL from D-glucaric acid derivatives may be prerequisite for their inhibition of chemical carcinogenesis in rodents and prevention of breast, prostate, and colon cancer in humans.

In vivo and in vitro Effects of Bromelain on PGE2 and SP Concentrations in the Inflammatory Exudate in Rats

The data indicate that bromelain reduces the production of two key mediators of inflammation, PGE2 and SP, which is related to a direct action of the drug on PGE1 and SP released in the exudate in response to the inflammatory stimulus.

Origins and evolution of the Western diet: health implications for the 21st century.

The evolutionary collision of the authors' ancient genome with the nutritional qualities of recently introduced foods may underlie many of the chronic diseases of Western civilization.

Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation.

Findings point to an immunomodulatory capacity of THE AUTHORS in adjuvant tumor therapy as well as an immunotoxic capacity of PMN against tumor cells in vitro and in vivo.

Possible involvement of eicosanoids in the pharmacological action of bromelain.

Results seem to indicate an interference of bromelain with arachidonic acid cascade, which deserves further investigation to be better assessed.

Enteropancreatic circulation of digestive enzyme as a conservation mechanism

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