An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

@article{Mardinoglu2018AnIU,
  title={An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.},
  author={Adil Mardinoglu and Hao Wu and Elias Bjornson and Cheng Zhang and Antti Hakkarainen and Sari M R{\"a}s{\"a}nen and Sunjae Lee and Rosellina Margherita Mancina and Mattias Bergentall and Kirsi Hannele Pietil{\"a}inen and Sanni S{\"o}derlund and Niina Matikainen and Marcus St{\aa}hlman and Per-Olof Bergh and Martin Adiels and Brian D Piening and Marit Gran{\'e}r and Nina Lundbom and Kevin J. Williams and Stefano Romeo and Jens B Nielsen and Michael P. Snyder and Mathias Uhl{\'e}n and G{\"o}ran Bergstr{\"o}m and Rosie S. Perkins and Hanns-Ulrich Marschall and Fredrik B{\"a}ckhed and Marja-Riitta Taskinen and Jan Bor{\'e}n},
  journal={Cell metabolism},
  year={2018},
  volume={27 3},
  pages={
          559-571.e5
        }
}
A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is lacking. Here, we performed a short-term intervention with an isocaloric low-carbohydrate diet with increased protein content in obese subjects with NAFLD and characterized the resulting alterations in metabolism and the gut microbiota using a multi-omics approach. We observed rapid and dramatic reductions of… CONTINUE READING
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