An Integrated Spatial Dynamics—Pharmacokinetic Model Explaining Poor Penetration of Anti-retroviral Drugs in Lymph Nodes

@article{Jagarapu2020AnIS,
  title={An Integrated Spatial Dynamics—Pharmacokinetic Model Explaining Poor Penetration of Anti-retroviral Drugs in Lymph Nodes},
  author={Aditya Jagarapu and M. Piovoso and R. Zurakowski},
  journal={Frontiers in Bioengineering and Biotechnology},
  year={2020},
  volume={8}
}
Although combined anti-retroviral therapy (cART) suppresses plasma HIV viremia below the limit of detection in a majority of HIV patients, evidence is emerging that the distribution of the anti-retroviral drugs is heterogeneous in tissue. Clinical studies measuring antiretroviral drug concentrations in lymph nodes (LNs) revealed lower concentrations compared to peripheral blood levels suggesting poor drug penetration properties. Our current study is an attempt to understand this poor anti… Expand
The Lymph Node Reservoir: Physiology, HIV Infection, and Antiretroviral Therapy
Pharmacology of HIV Cure: Site of Action

References

SHOWING 1-10 OF 52 REFERENCES
Complex patterns of viral load decay under antiretroviral therapy: influence of pharmacokinetics and intracellular delay.
Development of a Population Simulation Model for HIV Monotherapy Virological Outcomes Using Lamivudine
Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
Spatial modeling of HIV cryptic viremia and 2-LTR formation during raltegravir intensification.
Antiretroviral Tissue Kinetics: In Vivo Imaging Using Positron Emission Tomography
Studies on lymphoid tissue from HIV-infected individuals: implications for the design of therapeutic strategies
Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs
Modelling HIV-1 2-LTR dynamics following raltegravir intensification
...
1
2
3
4
5
...