An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.

@article{Cardnell2015AnIM,
  title={An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.},
  author={Robert J. G. Cardnell and Carmen Behrens and Lixia Diao and Youhong Fan and Ximing Tang and Pan Tong and John D. Minna and Gordon B. Mills and John V. Heymach and Ignacio Wistuba and Jing Wang and Lauren A. Byers},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2015},
  volume={21 15},
  pages={3480-91}
}
PURPOSE Thyroid transcription factor-1 (TTF1) immunohistochemistry (IHC) is used clinically to differentiate primary lung adenocarcinomas (LUAD) from squamous lung cancers and metastatic adenocarcinomas from other primary sites. However, a subset of LUAD (15%-20%) does not express TTF1, and TTF1-negative patients have worse clinical outcomes. As there are no established targeted agents with activity in TTF1-negative LUAD, we performed an integrated molecular analysis to identify potential… CONTINUE READING
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