An Integrated Clinico-transcriptomic Approach Identifies a Central Role of the Heme Degradation Pathway for Septic Complications after Trauma.

OBJECTIVE The present study was aimed to identify mechanisms linked to complicated courses and adverse events after severe trauma by a systems biology approach. SUMMARY BACKGROUND DATA In severe trauma, overwhelming systemic inflammation can result in additional damage and the development of complications, including sepsis. METHODS In a prospective… CONTINUE READING