An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle

@article{Gupta2013AnIG,
  title={An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle},
  author={Vikas Gupta and Matthew Gemberling and Ravi Karra and Gabriel E. Rosenfeld and Todd Evans and Kenneth D Poss},
  journal={Current Biology},
  year={2013},
  volume={23},
  pages={1221-1227}
}
A common principle of tissue regeneration is the reactivation of previously employed developmental programs. During zebrafish heart regeneration, cardiomyocytes in the cortical layer of the ventricle induce the transcription factor gene gata4 and proliferate to restore lost muscle. A dynamic cellular mechanism initially creates this cortical muscle in juvenile zebrafish, where a small number of internal cardiomyocytes breach the ventricular wall and expand upon its surface. Here, we find that… CONTINUE READING
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