An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery

  title={An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery},
  author={Christine R. Collins and Chrislaine Withers-Martinez and Fiona Hackett and Michael J. Blackman},
  journal={PLoS Pathogens},
Host cell invasion by apicomplexan pathogens such as the malaria parasite Plasmodium spp. and Toxoplasma gondii involves discharge of proteins from secretory organelles called micronemes and rhoptries. In Toxoplasma a protein complex comprising the microneme apical membrane antigen 1 (AMA1), two rhoptry neck proteins, and a protein called Ts4705, localises to the moving junction, a region of close apposition between parasite and host cell during invasion. Antibodies against AMA1 prevent… 

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