An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery
@article{Collins2009AnIA, title={An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery}, author={C. Collins and C. Withers-Martinez and F. Hackett and M. Blackman}, journal={PLoS Pathogens}, year={2009}, volume={5} }
Host cell invasion by apicomplexan pathogens such as the malaria parasite Plasmodium spp. and Toxoplasma gondii involves discharge of proteins from secretory organelles called micronemes and rhoptries. In Toxoplasma a protein complex comprising the microneme apical membrane antigen 1 (AMA1), two rhoptry neck proteins, and a protein called Ts4705, localises to the moving junction, a region of close apposition between parasite and host cell during invasion. Antibodies against AMA1 prevent… CONTINUE READING
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