An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery

@article{Collins2009AnIA,
  title={An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery},
  author={C. Collins and C. Withers-Martinez and F. Hackett and M. Blackman},
  journal={PLoS Pathogens},
  year={2009},
  volume={5}
}
  • C. Collins, C. Withers-Martinez, +1 author M. Blackman
  • Published 2009
  • Biology, Medicine
  • PLoS Pathogens
  • Host cell invasion by apicomplexan pathogens such as the malaria parasite Plasmodium spp. and Toxoplasma gondii involves discharge of proteins from secretory organelles called micronemes and rhoptries. In Toxoplasma a protein complex comprising the microneme apical membrane antigen 1 (AMA1), two rhoptry neck proteins, and a protein called Ts4705, localises to the moving junction, a region of close apposition between parasite and host cell during invasion. Antibodies against AMA1 prevent… CONTINUE READING
    162 Citations
    Apical membrane antigen 1 as an anti-malarial drug target.
    • 33
    Structural and Functional Insights into the Malaria Parasite Moving Junction Complex
    • 102
    • PDF

    References

    SHOWING 1-10 OF 38 REFERENCES
    Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species
    • 313
    • Highly Influential
    Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites.
    • 141
    • PDF
    The Most Polymorphic Residue on Plasmodium falciparum Apical Membrane Antigen 1 Determines Binding of an Invasion-Inhibitory Antibody
    • 119
    • PDF
    Molecular Identification of a Malaria Merozoite Surface Sheddase
    • 214
    • PDF
    Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens
    • 99
    Toxoplasma gondii Homologue ofPlasmodium Apical Membrane Antigen 1 Is Involved in Invasion of Host Cells
    • 162
    • Highly Influential
    • PDF