An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

@article{Srivastava2012AnIO,
  title={An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression},
  author={Mrinal Ranjan Srivastava and Mridula Nambiar and Sheetal Sharma and Subhas Somalingappa Karki and Gunaseelan Goldsmith and Mahesh V Hegde and Sujeet Kumar and Monica Pandey and Ram Kumar Singh and Pritha Ray and Renuka Natarajan and Madhura G. Kelkar and Abhijit De and Bibha Choudhary and Sathees C. Raghavan},
  journal={Cell},
  year={2012},
  volume={151},
  pages={1474-1487}
}
DNA Ligase IV is responsible for sealing of double-strand breaks (DSBs) during nonhomologous end-joining (NHEJ). Inhibiting Ligase IV could result in amassing of DSBs, thereby serving as a strategy toward treatment of cancer. Here, we identify a molecule, SCR7 that inhibits joining of DSBs in cell-free repair system. SCR7 blocks Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I. SCR7 inhibits NHEJ in a Ligase IV-dependent manner within… CONTINUE READING
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