An Increase in Extracellular Glutamate is a Sensitive Method of Detecting Ischaemic Neuronal Damage during Cranial Base and Cerebrovascular Surgery. An in Vivo Microdialysis Study

@article{Mendelowitsch1998AnII,
  title={An Increase in Extracellular Glutamate is a Sensitive Method of Detecting Ischaemic Neuronal Damage during Cranial Base and Cerebrovascular Surgery. An in Vivo Microdialysis Study},
  author={Aminadav Mendelowitsch and Laligam N. Sekhar and Donald C. Wright and Amal Nadel and Hiro Miyashita and Robert Richardson and Marc Kent and Ashfaq Shuaib},
  journal={Acta Neurochirurgica},
  year={1998},
  volume={140},
  pages={349-356}
}
All patients undergoing neurological surgery are at risk for serious complications. Ischaemic damage presenting with hemiparesis or speech difficulties occurs in up to 6% of patients undergoing cerebral bypass procedures and other complicated neurosurgical procedures. Currently available methods for detection of such damage include the use of somatosensory evoked potentials (SSEPs) and electro-encephalography (EEG). Unfortunately, these techniques have false positives and may remain normal in… CONTINUE READING

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