An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids

@inproceedings{Brudno2010AnIV,
  title={An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids},
  author={Yevgeny Brudno and Michael E Birnbaum and Ralph E Kleiner and David R Liu},
  booktitle={Nature chemical biology},
  year={2010}
}
Methods to evolve synthetic, rather than biological, polymers could significantly expand the functional potential of polymers that emerge from in vitro evolution. Requirements for synthetic polymer evolution include (i) sequence-specific polymerization of synthetic building blocks on an amplifiable template, (ii) display of the newly translated polymer strand in a manner that allows it to adopt folded structures, (iii) selection of synthetic polymer libraries for desired binding or catalytic… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Cload ST. SELEX with modified nucleotides

  • AD Keefe
  • Curr Opin Chem Biol
  • 2008

Similar Papers

Loading similar papers…