An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

@inproceedings{Katz2011AnIV,
  title={An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer},
  author={Elad Katz and Sylvie Dubois-Marshall and Andrew H Sims and Philippe Gautier and Helen Caldwell and Richard R. Meehan and David J. Harrison},
  booktitle={PloS one},
  year={2011}
}
The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells down-regulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility. In human breast cancer, invasion into surrounding tissue is the first step in metastatic progression. Here, we devised an in vitro model using selected cell lines, which recapitulates many features of EMT as observed in human breast cancer. By comparing the gene expression profiles of claudin… CONTINUE READING
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