An In-Silico Model of Lipoprotein Metabolism and Kinetics for the Evaluation of Targets and Biomarkers in the Reverse Cholesterol Transport Pathway

@inproceedings{Lu2014AnIM,
  title={An In-Silico Model of Lipoprotein Metabolism and Kinetics for the Evaluation of Targets and Biomarkers in the Reverse Cholesterol Transport Pathway},
  author={James Lu and Katrin H{\"u}bner and M. Nazeem Nanjee and Eliot A. Brinton and Norman A. Mazer},
  booktitle={PLoS Computational Biology},
  year={2014}
}
  • James Lu, Katrin Hübner, +2 authors Norman A. Mazer
  • Published in PLoS Computational Biology 2014
  • Biology, Computer Science, Medicine
  • High-density lipoprotein (HDL) is believed to play an important role in lowering cardiovascular disease (CVD) risk by mediating the process of reverse cholesterol transport (RCT). Via RCT, excess cholesterol from peripheral tissues is carried back to the liver and hence should lead to the reduction of atherosclerotic plaques. The recent failures of HDL-cholesterol (HDL-C) raising therapies have initiated a re-examination of the link between CVD risk and the rate of RCT, and have brought into… CONTINUE READING

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