An Improved Protocol for Efficient Engraftment in NOD/LTSZ-SCIDIL-2RγNULL Mice Allows HIV Replication and Development of Anti-HIV Immune Responses

Abstract

Cord blood hematopoietic progenitor cells (CB-HPCs) transplanted immunodeficient NOD/LtsZ-scidIL2Rγ(null) (NSG) and NOD/SCID/IL2Rγ(null) (NOG) mice need efficient human cell engraftment for long-term HIV-1 replication studies. Total body irradiation (TBI) is a classical myeloablation regimen used to improve engraftment levels of human cells in these… (More)
DOI: 10.1371/journal.pone.0038491

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@inproceedings{Singh2012AnIP, title={An Improved Protocol for Efficient Engraftment in NOD/LTSZ-SCIDIL-2RγNULL Mice Allows HIV Replication and Development of Anti-HIV Immune Responses}, author={Maneesh Kumar Singh and Pratibha Singh and Gilles Gaudray and Lucia Musumeci and Caroline Thielen and Dolor{\`e}s Vaira and Claire Vandergeeten and Laurence Delacroix and Ellen R A Van Gulck and G L E E Vanham and Laurence de Leval and Souad Rahmouni and Michel P. Moutschen}, booktitle={PloS one}, year={2012} }