An Improved Correlation Method Based on Rotation Invariant Feature for Automatic Particle Selection

  title={An Improved Correlation Method Based on Rotation Invariant Feature for Automatic Particle Selection},
  author={Yu Chen and Fei Ren and Xiaohua Wan and Xuan Wang and Fa Zhang},
Particle selection from cryo-electron microscopy (cryo-EM) images is very important for high-resolution reconstruction of macromolecular structure. However, the accuracy of existing selection methods are normally restricted to noise and low contrast of cryo-EM images. In this paper, we presented an improved correlation method based on rotation invariant features for automatic, fast particle selection. We first selected a preliminary particle set applying rotation invariant features, then… 
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  • A. Roseman
  • Computer Science
    Journal of structural biology
  • 2004
The potential and limitations of neutrons, electrons and X-rays for atomic resolution microscopy of unstained biological molecules.
Because of the lack of sufficiently bright neutron sources in the foreseeable future, electron microscopy in practice provides the greatest potential for immediate progress.