An Important Role for Type III Interferon (IFN-λ/IL-28) in TLR-Induced Antiviral Activity1

@article{Ank2008AnIR,
  title={An Important Role for Type III Interferon (IFN-$\lambda$/IL-28) in TLR-Induced Antiviral Activity1},
  author={Nina Ank and Marie Beck Iversen and C Bartholdy and Peter Staeheli and Rune Hartmann and Uffe Birk Jensen and Frederik Dagnaes-hansen and Allan Randrup Thomsen and Zhi Jian Chen and Harald S. Haugen and Kevin M. Klucher and Soren Riis Paludan},
  journal={The Journal of Immunology},
  year={2008},
  volume={180},
  pages={2474 - 2485}
}
Type III IFNs (IFN-λ/IL-28/29) are cytokines with type I IFN-like antiviral activities, which remain poorly characterized. We herein show that most cell types expressed both types I and III IFNs after TLR stimulation or virus infection, whereas the ability of cells to respond to IFN-λ was restricted to a narrow subset of cells, including plasmacytoid dendritic cells and epithelial cells. To examine the role of type III IFN in antiviral defense, we generated IL-28Rα-deficient mice. These mice… Expand
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