An Immunoscore Using PD-L1, CD68, and Tumor-infiltrating Lymphocytes (TILs) to Predict Response to Neoadjuvant Chemotherapy in Invasive Breast Cancer.

Abstract

Response to neoadjuvant chemotherapy (NAC) in invasive breast cancer (IBC) is partly regulated by the immune microenvironment. We evaluated immune checkpoint PD-L1 expression, presence of CD68+ cells of macrophage/monocytic lineage and stromal tumor-infiltrating lymphocytes (TILs) in prechemotherapy biopsies and correlated with NAC response. We studied 76… (More)
DOI: 10.1097/PAI.0000000000000485

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@article{McLemore2017AnIU, title={An Immunoscore Using PD-L1, CD68, and Tumor-infiltrating Lymphocytes (TILs) to Predict Response to Neoadjuvant Chemotherapy in Invasive Breast Cancer.}, author={Lauren E McLemore and Murali Janakiram and Joseph J Albanese and Nella Shapiro and Yungtai Lo and Xingxing Zang and Susan Fineberg}, journal={Applied immunohistochemistry & molecular morphology : AIMM}, year={2017} }