An Immunological Approach to the Biocompatibility of Mesoporous SiO2-CaO Nanospheres

  title={An Immunological Approach to the Biocompatibility of Mesoporous SiO2-CaO Nanospheres},
  author={M. Montes-Casado and Adrian Sanvicente and L. Casarrubios and M. Feito and J. Rojo and M. Vallet‐Reg{\'i} and D. Arcos and P. Portol{\'e}s and M. Portol{\'e}s},
  journal={International Journal of Molecular Sciences},
Mesoporous bioactive glass nanospheres (NanoMBGs) have high potential for clinical applications. However, the impact of these nanoparticles on the immune system needs to be addressed. In this study, the biocompatibility of SiO2-CaO NanoMBGs was evaluated on different mouse immune cells, including spleen cells subsets, bone marrow-derived dendritic cells (BMDCs), or cell lines like SR.D10 Th2 CD4+ lymphocytes and DC2.4 dendritic cells. Flow cytometry and confocal microscopy show that the… Expand
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