An Immuno-Biochip Selectively Captures Tumor-Derived Exosomes and Detects Exosomal RNAs for Cancer Diagnosis.

@article{Yang2018AnIS,
  title={An Immuno-Biochip Selectively Captures Tumor-Derived Exosomes and Detects Exosomal RNAs for Cancer Diagnosis.},
  author={Yunchen Yang and Eric D Kannisto and Guan Yu and Mary E. Reid and Santosh Patnaik and Yun Wu},
  journal={ACS applied materials & interfaces},
  year={2018},
  volume={10 50},
  pages={
          43375-43386
        }
}
Tumor-derived exosomes (TEXs) play instrumental roles in tumor growth, angiogenesis, immune modulation, metastasis, and drug resistance. TEX RNAs are a new class of noninvasive biomarkers for cancer. Neither current techniques, such as quantitative reverse transcription polymerase chain reaction (qRT-PCR) and next-generation sequencing, nor new ones, such as electrochemical or surface plasmon resonance-based biosensors, are able to selectively capture and separate TEXs from normal cell-derived… CONTINUE READING
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