An IkappaBalpha inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-kappaB-independent mechanism.

@article{Hu2001AnII,
  title={An IkappaBalpha inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-kappaB-independent mechanism.},
  author={Xiaotang Hu and William E Janssen and Lynn C. Moscinski and Matthew Bryington and A Dangsupa and Natalie Rezai-Zadeh and Brian A. Babbin and Kenneth S. Zuckerman},
  journal={Cancer research},
  year={2001},
  volume={61 16},
  pages={
          6290-6
        }
}
Treatment of U937 cells with an IkappaBalpha phosphorylation inhibitor, Bay 11-7085, induced a rapid phosphorylation of p38 mitogen-activated protein (MAP) kinase, significant apoptosis, extensive necrosis, and a weak phosphorylation of MAP kinase kinase. Bay 11-7085 had no effect on the basal levels of phosphorylated IkappaBalpha but completely inhibited phorbol 12-myristate 13-acetate-induced phosphorylation of IkappaBalpha. Although Bay 11-7085 prevented phorbol 12-myristate 13-acetate… CONTINUE READING
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