An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death.

@article{Schmitz2003AnIS,
  title={An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death.},
  author={Ingo Schmitz and Andreas Krueger and Sven Baumann and Henning Schulze-Bergkamen and Peter Heinrich Krammer and Sabine Kirchhoff},
  journal={Journal of immunology},
  year={2003},
  volume={171 6},
  pages={2930-6}
}
The CD95 (APO-1/Fas) system plays a critical role in activation-induced cell death (AICD) of T cells. We previously described two distinct CD95 (APO-1/Fas) signaling pathways: 1) type I cells show strong death-inducing signaling complex (DISC) formation and mitochondria-independent apoptosis and 2) DISC formation is reduced in type II cells, leading to mitochondria-dependent apoptosis. To investigate the relevance of these pathways, we set up an in vitro model that mimics the initiation and the… CONTINUE READING