An IGF binding protein is an inhibitor of FGF stimulation.

  title={An IGF binding protein is an inhibitor of FGF stimulation.},
  author={Jacqueline Villaudy and Jean Delb{\'e} and C. Blat and Genevieve Desauty and Alice Gold{\'e} and Liora Harel},
  journal={Journal of cellular physiology},
  volume={149 3},
We purified to homogeneity a growth inhibiting diffusible factor (IDF45) secreted by dense cultures of mouse 3T3 cells and which was able to inhibit 100% of DNA synthesis stimulated by serum in chick embryo fibroblasts (CEF) (Blat et al., 1989a). We then demonstrated that this factor was an IGF-binding protein (Blat et al., 1989b). Indeed, its N-terminal amino acid sequence was homologous to that of rat IGFBP-3. Our present results show that basic fibroblast growth factor (bFGF) induced… CONTINUE READING

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Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities.

American journal of physiology. Endocrinology and metabolism • 2000
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