An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice

@article{Roy2004AnHP,
  title={An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice},
  author={Cindy Norene Roy and {\'A}ngel O. Custodio and Jos de Graaf and Susanne Schneider and Imo U. Akpan and Lynne K. Montross and Mayka Sanchez and Alessandro Gaudino and Matthias W. Hentze and Nancy Catherine Andrews and Martina U. Muckenthaler},
  journal={Nature Genetics},
  year={2004},
  volume={36},
  pages={481-485}
}
Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces duodenal iron absorption and increases macrophage iron retention, resulting in low serum iron concentrations (hyposideremia). Despite the protection hyposideremia provides against proliferating microorganisms, this 'iron withholding' reduces the iron available to maturing red blood cells and… CONTINUE READING
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