An HIV-1-infected T cell clone defective in IL-2 production and Ca2+ mobilization after CD3 stimulation.

@article{Prez1991AnHT,
  title={An HIV-1-infected T cell clone defective in IL-2 production and Ca2+ mobilization after CD3 stimulation.},
  author={V{\'i}ctor L. P{\'e}rez and Thomas Rowe and Jesse S. Justement and Salvatore T. Butera and Carl H June and Thomas M. Folks},
  journal={Journal of immunology},
  year={1991},
  volume={147 9},
  pages={3145-8}
}
A chronically HIV-1-infected T cell clone (J1.1) derived from Jurkat cells was developed that possesses defects in CD3 signaling. This clone was phenotypically determined to be CD4- and express a reduced surface density of CD3 as compared with a pool of uninfected Jurkat clones. Although J1.1 could be induced with TNF-alpha to produce HIV-1 particles, stimulation via the CD3 (T3-Ti) complex, using mAb cross-linking, had no effect on viral production. Further investigation revealed that J1.1… CONTINUE READING