An H–YDb epitope is encoded by a novel mouse Y chromosome gene

@article{Greenfield1996AnHE,
  title={An H–YDb epitope is encoded by a novel mouse Y chromosome gene},
  author={Andy Greenfield and Diane M. Scott and David J. Pennisi and Ingrid Ehrmann and P. S. Ellis and Leanne Cooper and Elizabeth M. Simpson and Peter Koopman},
  journal={Nature Genetics},
  year={1996},
  volume={14},
  pages={474-478}
}
Rejection of male tissue grafts by genotypically identical female mice has been explained by the existence of a male-specific transplantation antigen, H-Y (ref. 1), but the molecular nature of H-Y antigen has remained obscure. Hya, the murine locus controlling H-Y expression, has been localized to ΔSxrb, a deletion interval of the short arm of the Y chromosome2. In mice, H–Y antigen comprises at least four distinct epitopes, each recognized by a specific T lymphocyte clone. It has recently been… Expand
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TLDR
The Hya/HYA gene(s) encoding H-Y antigen have been mapped using translocations, mutations, and deletions to Yq in humans and to the short arm of the Y chromosome in mice, where they lie in the deletion defined by the Sxrb mutation between Zfy-1 andZfy-2. Expand
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References

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TLDR
It is reported that Smcy encodes an H-YKk epitope that is defined by the octamer peptide TENSGKDI: no similar peptide is found in Smcx. Expand
Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus.
TLDR
Molecular, karyotypic, and immunological analysis of the deletion variants allowed us to define up to 16 ordered intervals and suggested an overall organization of Sxra and suggests that at least two and up to five distinct loci encode H-Y antigens. Expand
A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.
A new mouse Y chromosome gene, Smcy, has been isolated from the region encoding Spy, a spermatogenesis gene and Hya and Sdma, the genes that, respectively, control the expression of the male specificExpand
Location of the genes controlling H-Y antigen expression and testis determination on the mouse Y chromosome.
TLDR
It is concluded that the two linked genes Tdy and Hya, controlling testis determination and H-Y antigen expression, respectively, are located on the short arm of the mouse Y chromosome. Expand
A structural analysis of the Sxr region of the mouse Y chromosome.
TLDR
A preliminary model of the molecular structure of the DNA in this unique region of the mouse Y chromosome is presented and six distinct delta Sxrb loci have now been identified. Expand
A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.
TLDR
Two alleles of Smcx were found to be expressed in T(16;X)16H female mice despite the intact X chromosome being inactive in all cells, indicating that SmcX is also not subject to X-inactivation and provides the first example of a gene that is expressed from inactive and active X chromosomes in the mouse. Expand
Male sexual differentiation in mice lacking H–Y antigen
TLDR
It is reported here that H–Y is absent from certain mice that develop testes and are of indisputably male phenotype, hence this transplantation antigen is unlikely to be responsible for testis determination. Expand
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TLDR
It is shown that both the gene(s) controlling primary sex determination and the expression of the male-specific antigen H-Y are located on the minute short arm of the mouse Y chromosome. Expand
Major histocompatibility complex class I allele‐specific peptide libraries: Identification of peptides that mimic an H‐Y T cell epitope
TLDR
A degenerate synthetic peptide of limited complexity containing the identified H‐Y sequence motif was found to be similar to the natural H‐B‐restricted cytotoxic T lymphocyte epitope by reverse‐phase high performance liquid chromatography analysis. Expand
T cells with dual antigen specificity in T cell receptor transgenic mice rejecting allografts
TLDR
A T cell clone with dual antigen specificity is reported, isolated from an F5 TCR influenza nucleoprotein (NP 366–374/Db)‐specific transgenic female mouse which had rejected an H‐2‐matched male skin graft. Expand
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