An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice.

@article{Holland2013AnFA,
  title={An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice.},
  author={William L Holland and Andrew Charles Adams and Joseph T. Brozinick and Hai Hoang Bui and Yukiko Miyauchi and Christine M. Kusminski and Steven M Bauer and Mark Wade and Esha Singhal and Christine Kei Chin Cheng and Katherine Volk and Ming-shang Kuo and Ruth Gordillo and Alexei Kharitonenkov and Phillip E Scherer},
  journal={Cell metabolism},
  year={2013},
  volume={17 5},
  pages={790-7}
}
FGF21, a member of the fibroblast growth factor (FGF) superfamily, has recently emerged as a regulator of metabolism and energy utilization. However, the exact mechanism(s) whereby FGF21 mediates its actions have not been elucidated. There is considerable evidence that insulin resistance may arise from aberrant accumulation of intracellular lipids in insulin-responsive tissues due to lipotoxicity. In particular, the sphingolipid ceramide has been implicated in this process. Here, we show that… CONTINUE READING
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Receptormediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

  • W. L. Holland, R. A. Miller, +8 authors J.M
  • Nat. Med
  • 2011
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