An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors.

@article{Klein2008AnFS,
  title={An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors.},
  author={Ophir D Klein and David B. Lyons and Guive Balooch and Grayson William Marshall and M Albert Basson and Miroslav Peterka and Tom{\'a}{\vs} Bor{\'a}ň and Renata Peterkova and Gail R. Martin},
  journal={Development},
  year={2008},
  volume={135 2},
  pages={377-85}
}
Rodent incisors grow throughout adult life, but are prevented from becoming excessively long by constant abrasion, which is facilitated by the absence of enamel on one side of the incisor. Here we report that loss-of-function of sprouty genes, which encode antagonists of receptor tyrosine kinase signaling, leads to bilateral enamel deposition, thus impeding incisor abrasion and resulting in unchecked tooth elongation. We demonstrate that sprouty genes function to ensure that enamel-producing… CONTINUE READING