An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells.

@article{Calmont2006AnFR,
  title={An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells.},
  author={Am{\'e}lie Calmont and Ewa Wandzioch and Kimberly D Tremblay and George Minowada and Klaus H. Kaestner and Gail R. Martin and Kenneth S Zaret},
  journal={Developmental cell},
  year={2006},
  volume={11 3},
  pages={339-48}
}
While particular combinations of mesodermal signals are known to induce distinct tissue-specific programs in the endoderm, there is little information about the response pathways within endoderm cells that control their specification. We have used signaling inhibitors on embryo tissue explants and whole-embryo cultures as well as genetic approaches to reveal part of an intracellular network by which FGF signaling helps induce hepatic genes and stabilize nascent hepatic cells within the… CONTINUE READING

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