An Extract from the Medicinal Plant Phyllanthus acidus and Its Isolated Compounds Induce Airway Chloride Secretion: A Potential Treatment for Cystic Fibrosis

@article{Sousa2007AnEF,
  title={An Extract from the Medicinal Plant Phyllanthus acidus and Its Isolated Compounds Induce Airway Chloride Secretion: A Potential Treatment for Cystic Fibrosis},
  author={M. Sousa and J. Ousingsawat and Roswitha Seitz and Supaporn Puntheeranurak and A. Regalado and A. Schmidt and Tiago Grego and C. Jansakul and M. Amaral and R. Schreiber and K. Kunzelmann},
  journal={Molecular Pharmacology},
  year={2007},
  volume={71},
  pages={366 - 376}
}
According to previous reports, flavonoids and nutraceuticals correct defective electrolyte transport in cystic fibrosis (CF) airways. Traditional medicinal plants from China and Thailand contain phytoflavonoids and other bioactive compounds. We examined herbal extracts of the common Thai medicinal euphorbiaceous plant Phyllanthus acidus for their potential effects on epithelial transport. Functional assays by Ussing chamber, patch-clamping, double-electrode voltage-clamp and Ca2+ imaging… Expand
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In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract.
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