An Extensive Class of Small RNAs in Caenorhabditis elegans

@article{Lee2001AnEC,
  title={An Extensive Class of Small RNAs in Caenorhabditis elegans},
  author={Rosalind C. Lee and Victor Ambros},
  journal={Science},
  year={2001},
  volume={294},
  pages={862 - 864}
}
  • Rosalind C. Lee, V. Ambros
  • Published 26 October 2001
  • Biology, Medicine
  • Science
The lin-4 and let-7 antisense RNAs are temporal regulators that control the timing of developmental events inCaenorhabditis elegans by inhibiting translation of target mRNAs. let-7 RNA is conserved among bilaterian animals, suggesting that this class of small RNAs [microRNAs (miRNAs)] is evolutionarily ancient. Using bioinformatics and cDNA cloning, we found 15 new miRNA genes in C. elegans. Several of these genes express small transcripts that vary in abundance during C. elegans larval… 
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
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Two small temporal RNAs, lin-4 andlet-7, control developmental timing in Caenorhabditis elegans and are found to be members of a large class of 21- to 24-nucleotide noncodingRNAs, called microRNAs (miRNAs), which imply that, as a class, miRNAs have broad regulatory functions in animals.
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  • Biology, Medicine
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The idea that miRNAs have many targets and act to destabilize mRNA, was heretic at the time but turned out to be exactly right, suggests that the authors may be right to have such high hopes for these small RNAs.
MicroRNAs in Drosophila development.
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  • Biology, Medicine
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TLDR
This chapter discusses the current literature on the role of miRNAs as developmental regulators in Drosophila and highlights their importance as posttranscriptional regulators.
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Discovered in nematodes in 1993, microRNAs (miRNAs) are non-coding RNAs that are related to small interfering RNAs (siRNAs), the small RNAs that guide RNA interference (RNAi). miRNAs sculpt gene
Introduction to plant small RNAs
TLDR
The current knowledge on the three major types of plant small RNAs are summarized, with a focus on their biogenesis, modes of action, and local and systemic movement, as well as their regulatory function in plant development.
Micro-RNAs
TLDR
Two small temporally regulated RNAs (stRNAs)* of ∼22 nucleotides regulate timing of gene expression during development of the nematode C. elegans, suggesting a wide employment of stRNA-mediated gene regulation.
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Two small temporal RNAs, lin-4 andlet-7, control developmental timing in Caenorhabditis elegans and are found to be members of a large class of 21- to 24-nucleotide noncodingRNAs, called microRNAs (miRNAs), which imply that, as a class, miRNAs have broad regulatory functions in animals.
Identification of Novel Genes Coding for Small Expressed RNAs
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