An Extensive Class of Small RNAs in Caenorhabditis elegans

@article{Lee2001AnEC,
  title={An Extensive Class of Small RNAs in Caenorhabditis elegans},
  author={Rosalind C. Lee and Victor Ambros},
  journal={Science},
  year={2001},
  volume={294},
  pages={862 - 864}
}
The lin-4 and let-7 antisense RNAs are temporal regulators that control the timing of developmental events inCaenorhabditis elegans by inhibiting translation of target mRNAs. let-7 RNA is conserved among bilaterian animals, suggesting that this class of small RNAs [microRNAs (miRNAs)] is evolutionarily ancient. Using bioinformatics and cDNA cloning, we found 15 new miRNA genes in C. elegans. Several of these genes express small transcripts that vary in abundance during C. elegans larval… 
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Two small temporal RNAs, lin-4 andlet-7, control developmental timing in Caenorhabditis elegans and are found to be members of a large class of 21- to 24-nucleotide noncodingRNAs, called microRNAs (miRNAs), which imply that, as a class, miRNAs have broad regulatory functions in animals.
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microPrimer: the biogenesis and function of microRNA
Discovered in nematodes in 1993, microRNAs (miRNAs) are non-coding RNAs that are related to small interfering RNAs (siRNAs), the small RNAs that guide RNA interference (RNAi). miRNAs sculpt gene
Micro-RNAs
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Two small temporally regulated RNAs (stRNAs)* of ∼22 nucleotides regulate timing of gene expression during development of the nematode C. elegans, suggesting a wide employment of stRNA-mediated gene regulation.
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An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
TLDR
Two small temporal RNAs, lin-4 andlet-7, control developmental timing in Caenorhabditis elegans and are found to be members of a large class of 21- to 24-nucleotide noncodingRNAs, called microRNAs (miRNAs), which imply that, as a class, miRNAs have broad regulatory functions in animals.
Identification of Novel Genes Coding for Small Expressed RNAs
TLDR
It is shown that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs are highly conserved, which suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by smallRNAs are more general than previously appreciated.
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