An Extensive Class of Small RNAs in Caenorhabditis elegans

@article{Lee2001AnEC,
  title={An Extensive Class of Small RNAs in Caenorhabditis elegans},
  author={R. Lee and V. Ambros},
  journal={Science},
  year={2001},
  volume={294},
  pages={862 - 864}
}
  • R. Lee, V. Ambros
  • Published 2001
  • Medicine, Biology
  • Science
  • The lin-4 and let-7 antisense RNAs are temporal regulators that control the timing of developmental events inCaenorhabditis elegans by inhibiting translation of target mRNAs. let-7 RNA is conserved among bilaterian animals, suggesting that this class of small RNAs [microRNAs (miRNAs)] is evolutionarily ancient. Using bioinformatics and cDNA cloning, we found 15 new miRNA genes in C. elegans. Several of these genes express small transcripts that vary in abundance during C. elegans larval… CONTINUE READING

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