An Exposure-Response Curve for Copper Excess and Deficiency

@article{Chambers2010AnEC,
  title={An Exposure-Response Curve for Copper Excess and Deficiency},
  author={Andrea Chambers and Daniel Krewski and Nicholas Birkett and Laura M. Plunkett and Richard C. Hertzberg and Ruth Danzeisen and Peter J. Aggett and Thomas B. Starr and Scott Baker and M. Dourson and Paul Jones and Carl L Keen and Bette Meek and Rita S. Schoeny and Wouter H. Slob},
  journal={Journal of Toxicology and Environmental Health, Part B},
  year={2010},
  volume={13},
  pages={546 - 578}
}
There is a need to define exposure-response curves for both Cu excess and deficiency to assist in determining the acceptable range of oral intake. [...] Key Method A comprehensive database has been developed where different health outcomes from elevated and deficient Cu intakes were assigned ordinal severity scores to create common measures of response. A generalized linear model for ordinal data was used to estimate the probability of response associated with dose, duration and severity. The model can account…Expand
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