An Experimental Study of the Initiating Stage of Carcinogenesis, and a Re-examination of the Somatic Cell Mutation Theory of Cancer

@article{Berenblum1949AnES,
  title={An Experimental Study of the Initiating Stage of Carcinogenesis, and a Re-examination of the Somatic Cell Mutation Theory of Cancer},
  author={I. Berenblum and Philippe Shubik},
  journal={British Journal of Cancer},
  year={1949},
  volume={3},
  pages={109 - 118}
}
THOUGH non-carcinogenic to normal skin, croton oil elicits tumours in skin previously treated with a carcinogen for an inadequate period (Berenblum, 1941). This procedure, with the modification of Mottram (1944), using only one single application of carcinogen prior to the croton oil treatment, served as the basis of a quantitative analysis of carcinogenic response (Berenblum and Shubik, 1947b). The results led to the establishment of the essential difference in mechanism between the… CONTINUE READING

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_ rTAL , R . - - ( 1947 ) Cancer Res . , 7 , 390 . Idem AND SHBriK , P . - - ( 1947 a ) Brit

  • Idem A-D SCHOEN
  • 1947

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