An Experimental Approach To Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR– Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown

Abstract

Breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 2 (MRP2) are members of the ATP binding cassette (ABC) transporter family located in the canalicular membrane of hepatocytes that mediate biliary excretion of many drugs and endogenous compounds. BCRP and MRP2 have overlapping substrate profiles. Predicting drug disposition… (More)
DOI: 10.1021/mp400471e

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@inproceedings{Yang2014AnEA, title={An Experimental Approach To Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR– Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown}, author={Kyunghee Yang and Nathan D. Pfeifer and Rhiannon N. Hardwick and Wei Yue and Paul Wilder Stewart and Kim L. R. Brouwer}, booktitle={Molecular pharmaceutics}, year={2014} }