An Excel-based model of Ca2+ diffusion and fura 2 measurements in a spherical cell.

@article{McHugh2004AnEM,
  title={An Excel-based model of Ca2+ diffusion and fura 2 measurements in a spherical cell.},
  author={Jeannette M McHugh and James L. Kenyon},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={286 2},
  pages={C342-8}
}
We wrote a program that runs as a Microsoft Excel spreadsheet to calculate the diffusion of Ca2+ in a spherical cell in the presence of a fixed Ca2+ buffer and two diffusible Ca2+ buffers, one of which is considered to be a fluorescent Ca2+ indicator. We modeled Ca2+ diffusion during and after Ca2+ influx across the plasma membrane with parameters chosen to approximate amphibian sympathetic neurons, mammalian adrenal chromaffin cells, and rat dorsal root ganglion neurons. In each of these cell… CONTINUE READING

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