An Example of Gene Fixation Resulting from Selective Advantage in Suboptimal Conditions

  title={An Example of Gene Fixation Resulting from Selective Advantage in Suboptimal Conditions},
  author={Drew Schwartz},
  journal={The American Naturalist},
  pages={479 - 481}
  • D. Schwartz
  • Published 1 September 1969
  • Biology
  • The American Naturalist
In maize, alcohol dehydrogenase (enzyme commission occurs in the kernel and in the pollen. Enzyme activity falls off rapidly during seed germination (Efron and Schwartz 1968). As a result of treatment with the mutagen ethylmethane sulfonate (Schwartz, in preparation) we have induced a mutation at the Adhl locus which in homozygous condition fails to produce active enzyme. This mutant has been designated Adh10. Experiments are in progress to determine the nature of the mutation; however… 
Radiation-induced alcohol dehydrogenase mutants in maize following allyl alcohol selection of pollen
The Discussion considers the mutagenic action of ionizing radiation, and especially the well-documented differences between maize and Drosophila data, and the effect of these chromosome derangements on the ‘programmable’ component(s) of the Adhl cistron is discussed.
A Point Mutation of Adh1 Gene is Involved in the Repression of Coleoptile Elongation under Submergence in Rice
It is observed that, in the coleoptile, the Adh1 mRNA levels were comparable between the rad mutant and the wild type cultivar Kinmaze, while the amount of ADH1 protein was much lower in the rad mutants than in the wildtype.
Structure, expression, chromosomal location and product of the gene encoding ADH1 inPetunia
A genomic clone for an alcohol dehydrogenase (Adh) gene has been isolated fromPetunia hybrida cv. V30 by screening aPetunia genomic library with a maizeAdh1 probe. A combination of RFLP and allozyme
Molecular analyses of genetically stable mutants of the maize Adh1 gene
In general, EMS and ionizing radiation induce “point” lesions in Adh1 that, with few exceptions, do not alter the abundance or size of ADH1-RNA, or alter the gross genomic restriction map.
The reduced stability of a plant alcohol dehydrogenase is due to the substitution of serine for a highly conserved phenylalanine residue
The proximity of residue 144 to the catalytic zinc in the substrate-binding pocket, coupled with the fact that it is integral to a defined hydrophobic core of the ADH polypeptide, may explain the observed disruptive effect that the serine substitution has on both the activity and stability of theADH-1CN polypeptic.
Organ-specific expression of maize Adh1 is altered after a Mu transposon insertion.
A new, unstable, organ-specific Adh1 mutant was isolated from a Robertson's mutator line by germinating kernels under partial anaerobic conditions and was shown to express approximately 6% normal levels of ADH1 in seed and anaerobically treated seedlings but expresses normal levels in pollen, the male gametophyte.
Expression of two sucrose synthetase genes in endosperm and seedling cells of maize: evidence of tissue specific polymerization of protomers
The results from immuno-blot analyses show that the Sh encoded sucrose synthetase-1 protein (SS-1) is indeed present in seedlings and provides a new dimension and a useful tool for the analysis of many sh mutants and their revertants due to various transposable elements.
Genetics of sunflower alcohol dehydrogenase: Adh2,nonlinkage to Adh1and Adh1early alleles
  • A. Torres
  • Biology, Medicine
    Biochemical Genetics
  • 2004
Correlation between genotype and presence or absence of isozymes electrophoretically intermediate between those of Adh1 and Adh2 suggests that four intergenic isoz enzymes may be formed as a result of dimerization of the four basic subunits.


In vivo inactivation of maize alcohol dehydrogenase by a two-factor system.
  • Y. Efron, D. Schwartz
  • Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1968