An Examination of Water Vapor Sorption by Multi-Component Crystalline and Amorphous Solids and Its Effects on their Solid-State Properties.

@article{Newman2018AnEO,
  title={An Examination of Water Vapor Sorption by Multi-Component Crystalline and Amorphous Solids and Its Effects on their Solid-State Properties.},
  author={Ann E. Newman and George D Zografi},
  journal={Journal of pharmaceutical sciences},
  year={2018}
}
This commentary critically evaluated the unique effects of water vapor sorption by multi-component solid forms of active pharmaceutical ingredients (APIs), and its effects on their physical and chemical properties. Such multi-component forms include: 1) crystalline salts and cocrystals and 2) amorphous salts, coamorphous mixtures and amorphous solid dispersions (ASDs). These solid forms are commonly used to increase the solubility, dissolution, and bioavailability of poorly soluble APIs. To… CONTINUE READING
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