An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis

  title={An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis},
  author={Evangelos Vassos and Marta Di Forti and Jonathan D. Coleman and Conrad O. Iyegbe and Diana P. Prata and Jack Euesden and Paul O’Reilly and Charles J. C. Curtis and Anna Kolliakou and Hamel Patel and Stephen Newhouse and Matthew Traylor and Olesya Ajnakina and Valeria Mondelli and Tiago Reis Marques and Poonam Gardner-Sood and Katherine J Aitchison and John Powell and Zerrin Atakan and Kathryn E. Greenwood and Shubulade M Smith and Khalida Ismail and Carmine M Pariante and Fiona Gaughran and Paola Dazzan and Hugh S. Markus and Anthony S. David and Cathryn M. Lewis and Robin MacGregor Murray and Gerome Breen},
  journal={Biological Psychiatry},
BACKGROUND Polygenic risk scores (PRSs) have successfully summarized genome-wide effects of genetic variants in schizophrenia with significant predictive power. In a clinical sample of first-episode psychosis (FEP) patients, we estimated the ability of PRSs to discriminate case-control status and to predict the development of schizophrenia as opposed to other psychoses. METHODS The sample (445 case and 265 control subjects) was genotyped on the Illumina HumanCore Exome BeadChip with an… CONTINUE READING
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Psychosis Endophenotypes International Consortium, Wellcome Trust Case-Control Consortium

  • E Bramon, M Pirinen, A Strange, K Lin
  • Biol Psychiatry
  • 2014
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