An Evolutionary Reduction Principle for Mutation Rates at Multiple Loci

@article{Altenberg2011AnER,
  title={An Evolutionary Reduction Principle for Mutation Rates at Multiple Loci},
  author={Lee Altenberg},
  journal={Bulletin of Mathematical Biology},
  year={2011},
  volume={73},
  pages={1227-1270}
}
  • L. Altenberg
  • Published 14 September 2009
  • Mathematics, Medicine, Biology
  • Bulletin of Mathematical Biology
A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (Evolutionary Biology, vol. 14, pp. 61–204, 1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event models.A multivariate form of the reduction principle is found: reduction results at individual loci combine topologically to produce a surface of mutation rate alterations that are neutral for a new… 
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