An Evidence-Based Systematic Review of Gymnema (Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration

  title={An Evidence-Based Systematic Review of Gymnema (Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration},
  author={Catherine E. Ulbricht and Tracee Rae Abrams and Ethan M. Basch and Theresa Davies-Heerema and Ivo Foppa and Paul G. Hammerness and Erica Rusie and Shaina Tanguay-Colucci and Sarah Taylor and Catherine E. Ulbricht and Minney Varghese and Wendy Weissner and Jen Woods},
  journal={Journal Of Dietary Supplements},
  pages={311 - 330}
ABSTRACT An evidence-based systematic review of gymnema (Gymnema sylvestre R. Br.), including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. 
Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities
The result attained in this study indicated that the separation and characterization of these compounds play an important role in the research and development of new anti-diabetic drugs and pharmaceutical industry. Expand
Determination of gymnemic acid level in Gymnema inodorum leaves using multiple reaction monitoring mass spectrometry
Gymnemic acid (GA) is known as the antidiabetic phytoconstituent in Gymnema species, and is used for quality control and standardization of Gymnema products. In Thailand, a number of nutraceuticalExpand
Gymnena sylvestre in a therapy of diabetes mellitus
Gymnema sylvestre, známá pod jménem gurmar, je stálezelená liána původem z tropických oblastí Asie, Afriky a Austrálie, další výzkum pokračuje k léčbě mnoha onemocnění. Expand
Antifilarial Activity of Gymnema Sylvestre R. Br Leaves Against Brugia Malayi
  • V. Lakshmi
  • Chemistry
  • Biomedical Journal of Scientific & Technical Research
  • 2018
The present study is aimed to evaluate the anti-filarial activity of Gymnema sylvestre (Asclepiadaceae), against human lymphatic filarial parasite Brugia malayi in vitro and in vivo. The ethanolicExpand
Anti-obesity and Hypolipidemic Effects of GymnemaSyylvestre Leaves on Rats Fed on High Fat Diet
This work aimed to study the effects of high fat diet enriched with GymnemaSyylvestre leaves (GSL) on obese rats. Thirty (30) male albino rats weighting 150-160g used in this study and assigned to 5Expand
Anti-cancer effect of Gymnema sylvestre Leaf Extract against MG63, Human Osteosarcoma cell line - An in vitro analysis
G. sylvestre can be used as natural antioxidants for preventing the oxidative stress related degenerative diseases and can act as a promising free radical scavenger, anti-inflammatory and anticancer agent against MG63 human osteosarcoma cell lines. Expand
Herb-drug interactions: an overview of systematic reviews.
The majority of the HMPs evaluated in systematic reviews were not associated with drug interactions with serious consequences, however, the poor quality and the scarcity of the primary data prevent firm conclusions. Expand
Gymnemic acids lozenge reduces short-term consumption of high-sugar food: A placebo controlled experiment
The GA lozenge reduced candy consumption and desire for candy, providing novel evidence that blockade of sweet taste receptors reduces desire for sweet food, even before the food is tasted after GA dosing. Expand
Impact of Herbal Medicines on Conventional Drugs: An Overview
People misinterpret “natural” with “safe”. Unaware of the fact that herbal medicine contains pharmacological active constituents in unknown quantities; people use herbal medicinal products (HMPs)Expand
Development of a Building Block Strategy to Target the Classification, Identification, and Metabolite Profiling of Oleanane Triterpenoids in Gymnema sylvestre Using UHPLC-qTOF/MS.
A targeted, biosynthesis-inspired approach using UHPLC-qTOF/MS was implemented to elucidate the whole chemical profile of this plant for the standardization of the Vietnamese G. sylvestre variety, and 77 peaks were predicted to be new compounds based on their molecular formulas and mass fragmentation patterns. Expand


An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents.
Gymnema preparations have a profound action on the modulation of taste, particularly suppressing sweet taste sensations, and is used in the treatment of diabetes mellitus and in food additives against obesity and caries. Expand
New hypoglycemic constituents in "gymnemic acid" from Gymnema sylvestre.
Investigation of hypoglycemic activity of major saponin constituents from "gymnemic acid" exposed not only two new saponins, but also gymnemoside b and gymnemic acid V as active principles, and an acetyl group linked 16- or 22-hydroxy group in 1 and 2 was found to migrate easily to primary 28-hydroxyl group. Expand
Hypoglycaemic activity of an indigenous drug (Gymnema sylvestre, 'Gurmar') in normal and diabetic persons.
Recently, Gunnar has been shown to decrease blood glucose levels of normal fasting rabbits and it was considered worthwhile to evaluate hypoglycaemic activity of the drug in normal and diabetic persons. Expand
Constuents from Gymnema sylvestre leaves. V. Isolation and preliminary characterization of the gymnemic acids.
The objectives of this investigation were to isolate and characterize the constituents of gymnemic acid, the antisweet principle of Gymnema sylvestre leaves, and to make them available for furtherExpand
Human judgments of Gymnema sylvestre and sucrose mixtures.
The initial impression of sweetness of the mixture of G and sucrose was not different from the sweetness of a suitable control, and the lack of suppression was attributed to the relatively slow buildup of effect of G. Expand
Inhibition of the Sweet Taste by Gymnema sylvestre
Gymnema sylvestre, a plant used in the Ayurevedic medicine of India for the treatment of diabetes mellitus, selectively and temporarily reduces sensitivity to sweet substances. Expand
Comparative effects of chromium, vanadium and gymnema sylvestre on sugar-induced blood pressure elevations in SHR.
Chromium decreases the portion of SBP elevated by high sucrose intake as shown previously, but high levels of sucrose ingestion can eventually overcome this. Expand
Antimicrobial activity of Gymnema sylvestre leaf extract.
The ethanolic extract of Gymnema sylvestre leaves demonstrated antimicrobial activity against Bacillus pumilis, B. subtilis, Pseudomonas aeruginosa and Staphylococcus aureus and inactivity againstExpand
Suppression of glucose absorption by extracts from the leaves of Gymnema inodorum.
Effects of glucose availability of some saponin fractions extracted from GI leaves, which were obtained by high-performance liquid chromatography suggest that the component of GI inhibits the increase in the blood glucose level by interfering with the intestinal glucose absorption process. Expand
Effect of Gymnema sylvestre, R.Br. on glucose homeostasis in rats.
Results suggest the usefulness of G. sylvestre in the treatment of certain classes of non-insulin-dependent diabetes mellitus and show a tendency to reduce the serum glucose concentrations in the fed state and to improve the glucose tolerance. Expand