An Evaluation of Mass-Weighted Size Distribution Measurements with the Model 3320 Aerodynamic Particle Sizer

@article{Stein2002AnEO,
  title={An Evaluation of Mass-Weighted Size Distribution Measurements with the Model 3320 Aerodynamic Particle Sizer},
  author={Stephen W. Stein and Brian J. Gabrio and Derek R. Oberreit and Peter P. Hairston and Paul Myrdal and Tyler J. Beck},
  journal={Aerosol Science and Technology},
  year={2002},
  volume={36},
  pages={845 - 854}
}
The ability of the Model 3320 aerodynamic particle sizer (APS) to make accurate mass-weighted size distribution measurements was investigated. Significant errors were observed in APS size distribution measurements with measured mass median aerodynamic diameters (MMADs) as much as 17 times higher than from cascade impactor measurements. Analysis of APS correlated time-of-flight and light scattering data indicated that the MMAD distortions were due to a few anomalous large particle measurements… 
Evaluation of a new Aerodynamic Particle Sizer Spectrometer for size distribution measurements of solution metered dose inhalers.
TLDR
The ability of the Model 3320 and newer Model 3321 Aerodynamic Particle Sizer Spectrometer (APS) to make accurate mass-weighted size distribution measurements of solution metered dose inhalers (MDIs) was evaluated and was shown to be proportional to drug concentration to the one-third power.
Evaluation of Aerodynamic Particle Sizer and Electrical Low-Pressure Impactor for Unimodal and Bimodal Mass-Weighted Size Distributions
The objective of this study was to investigate the feasibility of the Aerodynamic Particle Sizer (APS) and the Electrical Low-Pressure Impactor (ELPI) to study mass weighted particle size
Concentration measurement and counting e ciency of the aerodynamic particle sizer 3321
Comparison of the Grimm 1.108 and 1.109 portable aerosol spectrometer to the TSI 3321 aerodynamic particle sizer for dry particles.
TLDR
This study compared the response of two optical particle counters with that of an aerodynamic particle sizer, finding systematic differences among instruments in number and mass concentration measurement that depended upon particle size.
A theoretical and experimental analysis of formulation and device parameters affecting solution MDI size distributions.
TLDR
Theoretical and empirical equations were developed that make it possible to predict the residual particle size distribution for solution MDIs.
An Algorithm for Combining Electrical Mobility and Aerodynamic Size Distributions Data when Measuring Ambient Aerosol Special Issue of Aerosol Science and Technology on Findings from the Fine Particulate Matter Supersites Program
Ambient aerosol particles vary in size from a few nanometers to several micrometers. No instrument is currently available to cover such a wide size range, and so a combination of several instruments
The Formation of Aerosol Particles from Solution-Based Pressurized Metered Dose Inhalers and Implications of Incomplete Droplet Drying: Theoretical and Experimental Comparison
The aerosol particle size distributions of solution-based pressurized metered dose inhalers containing 15%w/w ethanol and different quantities of nonvolatile component (NVC) (drug and glycerol) were
Aiming for a moving target: challenges with impactor measurements of MDI aerosols.
  • S. Stein
  • Environmental Science, Physics
    International journal of pharmaceutics
  • 2008
Investigation of influence factors on particle size measurement with pMDI
TLDR
These factors (environmental temperature and humidity, flow rate, and device temperature) had significant influence on the performance of LD or NGI, and should be controlled in the particle size measurement of pMDI.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
An approach to evaluating and correcting aerodynamic particle sizer measurements for phantom particle count creation.
An aerodynamic particle sizer (APS) can be used to make real-time measurements of the aerodynamic particle size distribution over the range of 0.5 to 32 microns. This instrument is very useful in
Inlet efficiency study for the TSI aerodynamic particle sizer
We report on the particle sampling efficiency of the inlet system for the Aerodynamic Particle Sizer (TSI, Inc., St. Paul MN). Large particles are depleted from the sampled aerosol by two mechanisms:
Calibration and Use of the Aerodynamic Particle Sizer (APS 3300)
The Aerodynamic Particle Sizer (APS) has been in use at the National Institute for Occupational Safety and Health (NIOSH) for over two years, beginning with a prototype model and more recently with a
Performance of a TSI aerodynamic particle sizer
Calibration curves of the aerodynamic particle sizer (APS) under different sets of operating conditions (i.e., pressure drop across the nozzle, flow rate, and ambient pressure) were obtained.
The Andersen impactor: Calibration, wall losses and numerical simulation
THE ASSOCIATION AND PARTICLE SIZE DISTRIBUTION OF DRUG AND SURFACTANT DISCHARGED FROM A METERED‐DOSE INHALATION AEROSOL
Hygroscopic d r u g p a r t i c l e s may i n c r e a s e i n s i z e when i n h a l e d (Gonda 1981) , a l t h o u g h t h e r e is r e c e n t e v i d e n c e t h a t s u r f a c t a n t s p r e s
Comparison of Cascade Impactor Data Reduction
  • 2001
Evaluation of a New Aerody
  • 2000
Evaluation of a New Aerodynamic Particle Sizer Spectrometer for MDI Size Distribution Measurements
  • Respiratory Drug Delivery VII
  • 2000
...
1
2
...