An Esterase-Sensitive Prodrug Approach for Controllable Delivery of Persulfide Species.

Abstract

A strategy to deliver a well-defined persulfide species in a biological medium is described. Under near physiological conditions, the persulfide prodrug can be activated by an esterase to generate a "hydroxymethyl persulfide" intermediate, which rapidly collapses to form a defined persulfide. Such persulfide prodrugs can be used either as chemical tools to… (More)
DOI: 10.1002/anie.201704117

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