An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms

@article{Hirose2009AnER,
  title={An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms},
  author={Tomonori Hirose and Daisuke Satoh and Hidetake Kurihara and Chiho Kusaka and Hiroko Hirose and Kazunori Akimoto and Taiji Matsusaka and Iekuni Ichikawa and Tetsuo Noda and Shigeo Ohno},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={2131 - 2147}
}
Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier in the renal glomerulus. Analyses of disease-causing mutations in familial nephrotic syndromes and targeted mutagenesis in mice have revealed critical roles of several proteins in the assembly of slit diaphragms. The nephrin-podocin complex is the main constituent of slit diaphragms. However, the… CONTINUE READING

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