An Essential Role for Talin during M 2-mediated Phagocytosis

@inproceedings{Lim2007AnER,
  title={An Essential Role for Talin during M 2-mediated Phagocytosis},
  author={Jenson Lim and Agn{\`e}s Wiedemann and George Tzircotis and Susan J. Monkley and David R. Critchley and Emmanuelle Caron},
  year={2007}
}
The cytoskeletal, actin-binding protein talin has been previously implicated in phagocytosis in Dictyostelium discoideum and mammalian phagocytes. However, its mechanism of action during internalization is not understood. Our data confirm that endogenous talin can occasionally be found at phagosomes forming around IgGand C3bi-opsonized red blood cells in macrophages. Remarkably, talin knockdown specifically abrogates uptake through complement receptor 3 (CR3, CD11b/CD18, M 2 integrin) and not… CONTINUE READING

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Endocytosis and the actin cytoskeleton in Dictyostelium discoideum.

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