An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis

@article{Hettmann1999AnER,
  title={An Essential Role for Nuclear Factor κB in Promoting  Double Positive Thymocyte Apoptosis },
  author={Thore Hettmann and Joseph A. DiDonato and Michael Karin and Jeffrey M. Leiden},
  journal={The Journal of Experimental Medicine},
  year={1999},
  volume={189},
  pages={145 - 158}
}
To examine the role of nuclear factor (NF)-kappaB in T cell development and activation in vivo, we produced transgenic mice that express a superinhibitory mutant form of inhibitor kappaB-alpha (IkappaB-alphaA32/36) under the control of the T cell-specific CD2 promoter and enhancer (mutant [m]IkappaB-alpha mice). Thymocyte development proceeded normally in the mIkappaB-alpha mice. However, the numbers of peripheral CD8(+) T cells were significantly reduced in these animals. The mIkappaB-alpha… CONTINUE READING