An Essential Role for DNA Methyltransferase DNMT3B in Cancer Cell Survival*

@article{Beaulieu2002AnER,
  title={An Essential Role for DNA Methyltransferase DNMT3B in Cancer Cell Survival*},
  author={Normand Beaulieu and Steves Morin and Ian C Chute and M. F. Robert and Hannah Nguyen and A. Robert Macleod},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={28176 - 28181}
}
Abnormal methylation and associated silencing of tumor suppressor genes is a common feature of many types of cancers. The observation of persistent methylation in human cancer cells lacking the maintenance methyltransferase DNMT1 suggests the involvement of other DNA methyltransferases in gene silencing in cancer. To test this hypothesis, we have evaluated methylation and gene expression in cancer cells specifically depleted of DNMT3A or DNMT3B,de novo methyltransferases that are expressed in… 

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